Multivariate Analysis of Factors Associated with Hemoglobin Levels among CKD Patients undergoing Hemodialysis

https://doi.org/10.33860/jik.v16i4.1545

Authors

  • Suhaimi Fauzan Universitas Tanjungpura, Pontianak, West Kalimantan, Indonesia
  • Kharisma Aji Martadi Universitas Tanjungpura, Pontianak, West Kalimantan, Indonesia https://orcid.org/0000-0001-6634-5464
  • Ikbal Fradianto Universitas Tanjungpura, Pontianak, West Kalimantan, Indonesia https://orcid.org/0000-0003-2408-5902
  • Muhammad Ali Maulana Universitas Tanjungpura, Pontianak, West Kalimantan, Indonesia
  • Herman Herman Universitas Tanjungpura, Pontianak, West Kalimantan, Indonesia

Keywords:

Risk Factor, Hemoglobin, Kidney failure, Hemodialysis

Abstract

Chronic Kidney Disease (CKD) is one of the silent killer diseases that often experience an increase in incidence every year. Common problem that often arises in someone with CKD is a decrease in hemoglobin levels. This study aims to identify and analyze factors related to hemoglobin levels among CKD patients undergoing hemodialysis. This was a correlational study with cross sectional approach. The study was conducted on March 21 – 31, 2022. The study population consisted of 90 CKD patients undergoing hemodialysis at Doctor Soedarso Regional General Hospital (as of January 2022). The samples involved 73 people who were selected using purposive sampling technique. The independent variables included age, gender, ethnicity, education, employment status, smoking history, creatinine and urea levels, while the dependent variable in this study was hemoglobin levels. Bivariate analysis in this study applied chi-square, Kendall’s, and independent sample t tests, while the multivariate test applied logistic regression. The analysis results obtained p values for age, employment status, smoking history, creatinine levels, and urea levels of 0.069 (OR=8.4), 0.418 (OR=2.4), 0.286 (OR=4.3), 0.000, and 0.323, respectively. It can be concluded that there was an effect of creatinine levels on changes in hemoglobin levels among CKD patients undergoing hemodialysis. Patients undergoing hemodialysis are recommended to control the amount and source of protein intake, adjust physical activity according to age and ability, and pay attention to the regular dialysis schedule

References

Carney EF. The impact of chronic kidney disease on global health. Nat Rev Nephrol [Internet]. 2020 May 6;16(5):251–251. Available from: http://www.nature.com/articles/s41581-020-0268-7

Saminathan TA, Hooi LS, Mohd Yusoff MF, Ong LM, Bavanandan S, Rodzlan Hasani WS, et al. Prevalence of chronic kidney disease and its associated factors in Malaysia; findings from a nationwide population-based cross-sectional study. BMC Nephrol [Internet]. 2020 Dec 14;21(1):344. Available from: https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-020-01966-8

Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, et al. Global, Regional, and National Burden of Chronic Kidney Disease, 1990–2017: a Systematic Analysis for the Global Burden of Disease Study 2017. Lancet [Internet]. 2020 Feb;395(10225):709–33. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0140673620300453

Ammirati AL. Chronic Kidney Disease. Rev Assoc Med Bras [Internet]. 2020;66(suppl 1):s03–9. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001300003&tlng=en

Kumar V, Abbas AK, Aster JC. Ginjal dan Sistem Pengumpul. In: Robbins Basic Pathology. Edisi 9. Philadelphia, USA: Elsevier; 2015. p. 517.

Hanna RM, Streja E, Kalantar-Zadeh K. Burden of Anemia in Chronic Kidney Disease: Beyond Erythropoietin. Adv Ther [Internet]. 2021 Jan 29;38(1):52–75. Available from: http://link.springer.com/10.1007/s12325-020-01524-6

Barinda AJ, Arozal W, Wahyuni UT. Statin Mencegah Penurunan Kadar Hemoglobin dan Parameter Hematologi Lainnya pada Model Tikus Gagal Ginjal Eksperimental. J Med Heal [Internet]. 2021 Aug 17;3(2). Available from: https://journal.maranatha.edu/index.php/jmh/article/view/3332

Rajagukguk M. Hubungan antara Lama Hemodialisa dan Faktor Komorbiditas dengan Kematian Pasien gagal Ginjal Kronik di RSUD DR. Pringadi Medan. J Ilm Maksitek [Internet]. 2019;4(2):5. Available from: https://makarioz.sciencemakarioz.org/index.php/JIM/article/view/83/80

Bhagat N, Dawman L, Naganur S, Tiewsoh K, Kumar B, Pratyusha K, et al. Impact of anemia on the cardiovascular status in children with chronic kidney disease: A pilot study. Clin Nutr ESPEN [Internet]. 2021 Dec; Available from: https://linkinghub.elsevier.com/retrieve/pii/S2405457721011438

Lisnawati E, Sintowati R, Lestari N, Nursanto D. Hubungan Antara Kadar Hemoglobin, Indeks Massa Tubuh, Dan Tekanan Darah Terhadap Kualitas Hidup Pasien Gagal Ginjal Kronik. In: Proceeding Book National Symposium and Workshop Continuing Medical Education XIV [Internet]. Surakarta: UMS; 2021. p. 776–87. Available from: https://publikasiilmiah.ums.ac.id/xmlui/bitstream/handle/11617/12788/66.pdf?sequence=1&isAllowed=y

Kurniawati S, Wibrata DA, Anugrahini HN. Faktor-Faktor yang Mempengaruhi Anemia Pada Klien Gagal Ginjal Kronik yang Menjalani Hemodialisa di Rumah Sakit Islam Jemursari Surabaya. J Keperawatan [Internet]. 2018;11(3):133–41. Available from: http://journal.poltekkesdepkes-sby.ac.id/index.php/KEP/article/view/1471/835

Retni A, Ayuba A. Faktor – Faktor Yang Berhubungan Dengan Kejadian Anemia Pada Pasien Penyakit Gagal Ginjal Kronik Di Ruang Hemodialisa Rsud Prof. Dr. H. Aloei Saboe Kota Gorontalo. J Zaitun [Internet]. 2016;4(1). Available from: https://journal.umgo.ac.id/index.php/Zaitun/article/view/1230

Hamidah L. Gambaran Faktor-Faktor Perilaku Ibu terhdap Pemberian ASI dengan Pendekatan Helath Belief Model di Wilayah Kerja Puskesmas Setu Tanggerang Selatan [Internet]. Cetakan Pe. UIN Syarif Hidayatullah Jakarta; 2017. Available from: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwj5svDInY39AhV0_XMBHQMxAcQQFnoECA4QAQ&url=https%3A%2F%2Frepository.uinjkt.ac.id%2Fdspace%2Fbitstream%2F123456789%2F36736%2F1%2FLisnani%2520Hamidah-FKIK.pdf&usg=AOvVaw1

Indriani V, Purwanto, Kusmiyati, Juniarto AZ, Indranila. The Differences Of 25-Hydroxyvitamin D Levels, Leucocyte Count, Neutrophil Limfocyte Ratio Dan C-Reactive Protein In Elderly With Anemia And Non-Anemia. Prosiding [Internet]. 2021;10(1). Available from: http://eprints.undip.ac.id/71107/8/cover_Tesis_S2_vitasari_indriani.pdf

Ladaninejad S, Ilali E, Mousavinasab N, Taraghi Z. The Relationship between Depressive Symptoms and Demographic-Medical Characteristics among Elder People with Cancer. Asia-Pacific J Oncol Nurs [Internet]. 2019 Oct;6(4):424–30. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2347562521002006

Tan LH, Chen PS, Chiang HY, King E, Yeh HC, Hsiao YL, et al. Insomnia and Poor Sleep in CKD: A Systematic Review and Meta-analysis. Kidney Med [Internet]. 2022 May;4(5):100458. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2590059522000711

Jackowska M, Kumari M, Steptoe A. Sleep and Biomarkers in the English Longitudinal Study of Ageing: Associations with C-reactive Protein, Fibrinogen, Dehydroepiandrosterone sulfate and Hemoglobin. Psychoneuroendocrinology [Internet]. 2013 Sep;38(9):1484–93. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0306453012004283

Shin JY, Shim JY. Low vitamin D levels increase anemia risk in Korean women. Clin Chim Acta [Internet]. 2013 Jun;421:177–80. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0009898113000806

Duncan JA, Levin A. Sex, haemoglobin and kidney disease: new perspectives. Eur J Clin Invest [Internet]. 2005 Dec;35(s3):52–7. Available from: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2362.2005.01531.x

Saran R, Robinson B, Abbott KC, Agodoa LYC, Albertus P, Ayanian J, et al. US Renal Data System 2016 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis [Internet]. 2017 Mar;69(3):A7–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S027263861630703X

Ho LT, Sprague SM. Women and CKD-Mineral and Bone Disorder. Adv Chronic Kidney Dis [Internet]. 2013 Sep;20(5):423–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1548559513000840

Surya A fauza, Pane AH, Lubis EH. Perbedaan Konsentrasi Hemoglobin Wanita Hamil Trimester III antara Suku Jawa dan Suku Batak. J Kedokt Ibnu Nafis [Internet]. 2020;9(1):27–31. Available from: https://jurnal.fk.uisu.ac.id/index.php/ibnunafis/article/view/53

Chu CD, Powe NR, McCulloch CE, Crews DC, Han Y, Bragg-Gresham JL, et al. Trends in Chronic Kidney Disease Care in the US by Race and Ethnicity, 2012-2019. JAMA Netw Open [Internet]. 2021 Sep 27;4(9):e2127014. Available from: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2784527

Atkinson MA, Pierce CB, Zack RM, Barletta GM, Yadin O, Mentser M, et al. Hemoglobin Differences by Race in Children With CKD. Am J Kidney Dis [Internet]. 2010 Jun;55(6):1009–17. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0272638610001198

Negara IC, Prabowo A. Penggunaan Uji Chi–Square untuk Mengetahui Pengaruh Tingkat Pendidikan dan Umur terhadap Pengetahuan Penasun Mengenai HIV–AIDS di Provinsi DKI Jakarta. Pros Semin Nas Mat dan Ter 2018 [Internet]. 2018;1–8. Available from: http://matematika.fmipa.unsoed.ac.id/wp-content/uploads/3.-igo-dkk.pdf

Solihatin Y, Mu’Min MF. Pengaruh Pendidikan Kesehatan Terhadap Tingkat Pengetahuan Self Management Pasien Chronic Kidney Disease (CKD) Di Ruang Hemodialisa RSUD SMC Tasikmalaya. J Mitra Kencana Keperawatan Dan Kebidanan [Internet]. 2021 Apr 9;4(2). Available from: http://www.jurnal.ubktasikmalaya.ac.id/index.php/jmk_kb/article/view/106

Liow FM, Kapantow NH, Malonda N. Hubungan antara status sosial ekonomi dengan anemia pada ibu hamil di desa sapa kecamatan tenga kabupaten Minahasa selatan [Internet]. Universitas Sam Ratulangi; 2012. Available from: https://fkm.unsrat.ac.id/wp-content/uploads/2013/08/M.-Liow.pdf

Hoshino J, Muenz D, Zee J, Sukul N, Speyer E, Guedes M, et al. Associations of Hemoglobin Levels With Health-Related Quality of Life, Physical Activity, and Clinical Outcomes in Persons With Stage 3-5 Nondialysis CKD. J Ren Nutr [Internet]. 2020 Sep;30(5):404–14. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1051227619304145

Gregg LP, Bossola M, Ostrosky-Frid M, Hedayati SS. Fatigue in CKD. Clin J Am Soc Nephrol [Internet]. 2021 Sep;16(9):1445–55. Available from: https://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.19891220

Morton RL, Schlackow I, Gray A, Emberson J, Herrington W, Staplin N, et al. Impact of CKD on Household Income. Kidney Int Reports [Internet]. 2018 May;3(3):610–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2468024917304795

Handayani NS, Astuti NFW. Analisis Kadar Hemoglobin pada Wanita Perokok dan Wanita Bukan Perokok di Indonesia ( Analisis Matching Sampel menggunakan Data IFLS 5 ). Med Respati J Ilm Kesehat [Internet]. 2022;17(1):1–12. Available from: http://repository.unej.ac.id/xmlui/handle/123456789/107161

AlQahtany FS, Algahtani FH, Alshebly MM, Madkhaly FM, Ghandour MK, Almalki JH, et al. Association Between Cigarette & Shisha Smoking and the Severity of Polycythemia: A cross Sectional Study. Saudi J Biol Sci [Internet]. 2020 Jan;27(1):460–4. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1319562X19302438

Wang S, Qin A, Pei G, Jiang Z, Dong L, Tan J, et al. Cigarette Smoking may Accelerate the Progression of IgA Nephropathy. BMC Nephrol [Internet]. 2021 Dec 29;22(1):239. Available from: https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-021-02453-4

Latifah I, Suswardany DL, Kusumawati Y. Hubungan Antara Kadar Hemoglobin, Kadar Albumin, Kadar Kreatinin dan Status Pembayaran dengan Kematian Pasien Gagal Ginjal Kronik di RSUD Dr. Moewardi Surakarta. J Kesehat [Internet]. 2012;5(1):83–92. Available from: http://hdl.handle.net/11617/3070

Rosnety M, Arif H. Hubungan Antara Kadar Hemoglobin Dengan Kadar Kreatinin Serum Penderita Penyakit Ginjal Menahun (Kronis). Indones J Clin Pathol Med Lab [Internet]. 2018 Mar 15;13(3):97. Available from: https://indonesianjournalofclinicalpathology.org/index.php/patologi/article/view/908

Seki M, Nakayama M, Sakoh T, Yoshitomi R, Fukui A, Katafuchi E, et al. Blood Urea Nitrogen Is Independently Associated With Renal Outcomes In Japanese Patients With Stage 3–5 Chronic Kidney Disease: A Prospective Observational Study. BMC Nephrol [Internet]. 2019 Dec 2;20(1):115. Available from: https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-019-1306-1

Ma ’shumah N, Bintanah S, Handarsari E. Hubungan Asupan Protein dengan Kadar Ureum, Kreatinin, dan Kadar Hemoglobin Darah Pada penderita Gagal Ginjal Kronik Hemodialisa Rawat Jalan di RS Tugurejo Semarang. J Gizi Univ Muhammadiyah Semarang [Internet]. 2014;3(1):22–32. Available from: https://doi.org/10.26714/jg.3.1.2014.%25p

Cases A, Cigarrán-Guldrís S, Mas S, Gonzalez-Parra E. Vegetable-Based Diets for Chronic Kidney Disease? It Is Time to Reconsider. Nutrients [Internet]. 2019 Jun 4;11(6):1263. Available from: https://www.mdpi.com/2072-6643/11/6/1263

Kim HJ, Kim TE, Han M, Yi Y, Jeong JC, Chin HJ, et al. Effects of Blood Urea Nitrogen Independent of the Estimated Glomerular Filtration Rate on the Development of Anemia in Non-dialysis Chronic Kidney Disease: The Results of the KNOW-CKD Study. Wu PH, editor. PLoS One [Internet]. 2021 Sep 10;16(9). Available from: https://dx.plos.org/10.1371/journal.pone.0257305

Ko GJ, Rhee CM, Kalantar-Zadeh K, Joshi S. The Effects of High-Protein Diets on Kidney Health and Longevity. J Am Soc Nephrol [Internet]. 2020 Aug;31(8):1667–79. Available from: https://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2020010028

Hinkle JL, Cheever KH. Chronic Iilness. In: Brunner & Suddarth’s textbook of medical-surgical nursing [Internet]. Edisi 13. New York: Lippincott Williams & Wilkins; 2014. p. 146–57. Available from: https://rspmanguharjo.jatimprov.go.id/wp-content/uploads/2020/02/11.-Handbook-for-Brunner-and-Suddarths-Textbook-of-Medical-Surgical-Nursing-12th-Edition-Suzann.pdf

Sudoyo AW. Buku Ajar Ilmu Penyakit Dalam. Edisi 6. Jakarta Pusat: InternaPublishing; 2014.

PPNI. Standar Diagnosis Keperawatan Indonesia. 1st ed. Jakarta: DPP PPNI RI; 2017.

Kallenbach J. Review of Hemodialysis for Nurses and Dialysis Personnel. 9th ed. Missouri: Mosby Elsevier; 2015. 431.

Published

2023-02-28

How to Cite

Fauzan, S. ., Martadi, K. A. ., Fradianto, I. ., Maulana, M. A. ., & Herman, H. (2023). Multivariate Analysis of Factors Associated with Hemoglobin Levels among CKD Patients undergoing Hemodialysis . Poltekita : Jurnal Ilmu Kesehatan, 16(4), 443–452. https://doi.org/10.33860/jik.v16i4.1545

Issue

Section

Original Articles

Similar Articles

1 2 3 4 5 6 7 8 9 > >> 

You may also start an advanced similarity search for this article.