Examining the Impact of Candlenut Fruit Extract Cream on Hair Growth in Male Wistar Rats (Rattus norvegicus)

https://doi.org/10.33860/jik.v17i4.3613

Authors

  • Anche Pratiwi Fitriani Department of Biomedicine, University of Prima Indonesia, Medan, Indonesia
  • Johana Fransiska Wijaya Department of Biomedicine, University of Prima Indonesia, Medan, Indonesia
  • Juliana Lina Department of Biomedicine, University of Prima Indonesia, Medan, Indonesia
  • Dewi Fibrini Department of Biomedicine, University of Prima Indonesia, Medan, Indonesia

Keywords:

Candlenut, Hair Loss, Follicles, Hair Health

Abstract

Hair loss can affect mental health. Natural compound-based hair treatments like candlenut fruit are becoming more popular due to their low side effects and growing scientific research on hair loss. This study aims to prove the effectiveness of candlenut fruit extract cream on the hair growth of male Wistar strain rats (Rattus norvegicus). Research method Laboratory experiment, Principle 3R (Replacement, Reduction, and Refinement): Reducing Rattus norvegicus Wistar male strain samples The 20 male rats in this study will be divided into four groups. Hair growth is examined with 5%, 10%, and 15% candlenut fruit extract cream. Research data was analyzed using SPSS. The results of testing hair growth in rats with 5%, 10%, and 15% doses of candlenut fruit extract cream were normally distributed. The control group had a significant value of 0.928 > 0.05, treatment group 1 had a value of 0.579 > 0.05, treatment group 2 of 0.829 > 0.05, and treatment group 3 of 0.451 > 0.05. Candlenut fruit extract cream is effective for increasing hair growth in Rattus norvegicus. This study concludes that candlenut fruit extract cream can accelerate the development of hair follicles in Wistar strain male white rats. Due to the heated manufacturing process, candlenut extract is safe to use.

References

Gokalp H. Psychosocial Aspects of Hair Loss. Hair and Scalp Disorders. 2017 May 3;

Kesika P, Sivamaruthi BS, Thangaleela S, Bharathi M, Chaiyasut C. Role and Mechanisms of Phytochemicals in Hair Growth and Health. Pharmaceuticals 2023, Vol 16, Page 206 [Internet]. 2023 Jan 30 [cited 2024 Feb 9];16(2):206. Available from: https://www.mdpi.com/1424-8247/16/2/206/htm

Vogt A, McElwee KJ, Blume-Peytavi U. Biology of the hair follicle. Hair, Hair Growth and Hair Disorders [Internet]. 2008 [cited 2024 Feb 9];1–22. Available from: https://link.springer.com/chapter/10.1007/978-3-540-46911-7_1

Erdoğan B. Anatomy and Physiology of Hair. Hair and Scalp Disorders. 2017 May 3;

Brown TM, Krishnamurthy K. Histology, Hair and Follicle [Internet]. StatPearls Publishing, Treasure Island (FL); 2023. Available from: http://europepmc.org/abstract/MED/30422524

Park AM, Khan S, Rawnsley J. Hair Biology: Growth and Pigmentation. Facial Plast Surg Clin North Am [Internet]. 2018 Nov 1 [cited 2024 Feb 9];26(4):415–24. Available from: http://www.facialplastic.theclinics.com/article/S1064740618300270/fulltext

Daniels G, Akram S, Westgate GE, Tamburic S. Can plant-derived phytochemicals provide symptom relief for hair loss? A critical review. Int J Cosmet Sci [Internet]. 2019 Aug 1 [cited 2024 Feb 12];41(4):332–45. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/ics.12554

Broadley D, McElwee KJ. A “hair-raising” history of alopecia areata. Exp Dermatol [Internet]. 2020 Mar 1 [cited 2024 Feb 9];29(3):208–22. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/exd.14073

Al-Refu K. Hair Loss in Children, Etiologies, and Treatment. In: Hair and Scalp Disorders. InTech; 2017.

Fabbrocini G, Cantelli M, Masarà A, Annunziata MC, Marasca C, Cacciapuoti S. Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review. Int J Womens Dermatol. 2018 Dec 1;4(4):203–11.

Legiawati L. Jenis kerontokan rambut dan kebotakan pasien poliklinik kulit dan kelamin rsupn dr. cipta mangunkusumo tahun 2009-2011. Departemen Ilmu Kesehatan Kulit dan Kelamin FK Universitas Indonesia/RSUPN dr Cipto Mangunkusumo, Jakarta. 2013;40(4):159–63.

Saifullah M, Shishir MRI, Ferdowsi R, Tanver Rahman MR, Van Vuong Q. Micro and nanoencapsulation, retention and controlled release of flavor and aroma compounds: A critical review. Trends Food Sci Technol. 2019 Apr 1;86:230–51.

Nedovic V, Kalusevic A, Manojlovic V, Levic S, Bugarski B. An overview of encapsulation technologies for food applications. Procedia Food Sci. 2011 Jan 1;1:1806–15.

Hidayat AF, Aryani R, Choesrina R, Novita ID, Devi AM. Oxidative Stability of Nano-Encapsulated Candlenut Oil. KnE Life Sciences [Internet]. 2022 Dec 27 [cited 2024 Feb 12];2022:282-289–282–289. Available from: https://knepublishing.com/index.php/KnE-Life/article/view/12537

Yusri S, Meidiana C, Marpaung AM, Sutanto H. Encapsulation of candlenut oil by freeze-drying method. Journal of Functional Food and Nutraceutical [Internet]. 2020 Aug 31 [cited 2024 Feb 9];2(1):53–61. Available from: https://journal.sgu.ac.id/jffn/index.php/jffn/article/view/35

Yusri S, Meidiana C, Marpaung AM, Sutanto H. Encapsulation of candlenut oil by freeze-drying method. Journal of Functional Food and Nutraceutical [Internet]. 2020 Aug 31 [cited 2024 Feb 9];2(1):53–61. Available from: https://journal.sgu.ac.id/jffn/index.php/jffn/article/view/35

Erawati TM, Rosita N, Rachmania I. The activity of candlenut oil in the nanostructured lipid carrier system on hair growth in rats. J Public Health Afr. 2023;

Notoatmodjo S. Metodologi Penelitian Kesehatan. 3rd ed. Jakarta: Rineka Cipta; 2022. 268 p.

Mishra P, Singh U, Pandey CM, Mishra P, Pandey G. Application of Student’s t-test, Analysis of Variance, and Covariance. Ann Card Anaesth [Internet]. 2019 [cited 2024 Feb 9];22(4):407. Available from: /pmc/articles/PMC6813708/

NRC N. Guide for the Care and Use of Laboratory Animals. 8th ed. Vol. 39, The Physiologist. Washington, D.C.: National Academy Press; 2011. 246 p.

Kendall L V., Owiny JR, Dohm ED, Knapek KJ, Lee ES, Kopanke JH, et al. Replacement, Refinement, and Reduction in Animal Studies With Biohazardous Agents. ILAR J. 2018;59(2):177–94.

Wan Mohammad WMZ. Sample Size Calculation in Animal Studies Using Resource Equation Approach. Malaysian Journal of Medical Sciences. 2017;24(5):101–5.

Ghozali I. Aplikasi Analisis Multivariate dengan Program IBM SPSS 25. Badan Penerbit Universitas Diponegoro. Semarang; 2018.

Tosti A, Schwartz JR, Frost P, James Schwartz CR. Role of scalp health in achieving optimal hair growth and retention. Int J Cosmet Sci [Internet]. 2021 Nov 1 [cited 2024 Feb 12];43(S1):S1–8. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/ics.12708

Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatol Ther (Heidelb). 2019 Mar 13;9(1):51–70.

Kutlubay Z, Serdaroglu S. Introductory Chapter: Hair Loss. In: Hair and Scalp Disorders. InTech; 2017.

Tasya Salsabila, Wanda Indriyani, Sari Y, Nia Yuniarsih. Utilization of Aloe vera Plants as a Raw Materials for Cosmetics: A Narrative Review. Open Access Indonesian Journal of Medical Reviews. 2022;2(4):259–64.

Misde Yola, Agung Wibowo, Shelly Taurhesia. Activity and safety test combination of garlic extract (Alium satsuma) and candlenut extract(Aleurites molucanna) as fertilizer rabbit fur. International Journal of Research in Pharmaceutical Sciences. 2021;12(3):1780–7.

Miftahurahma NML, Andriyanto, Manalu W, Ilyas AZ. Efektivitas Minyak Kemiri (Aleurites moluccana L.) sebagai Penumbuh Rambut pada Tikus (Rattus norvegicus). Jurnal Veteriner dan Biomedis. 2023;1(2):65–71.

Almas JF, Chasanah U, Rahmasari D. Activity of Hair Tonic Nanoemulsion with Candlenut Oil (Aleurites Moluccana) on Mice (Mus Musculus). KnE Medicine [Internet]. 2022 Sep 15 [cited 2024 Feb 12];630-636–630–636. Available from: https://knepublishing.com/index.php/KnE-Medicine/article/view/11917

Rahman Mat Amin A, Abu Bakar R, Jaafar R. The effectiveness of coconut oil mixed with herbs to promote hair growth. International Journal of Ethics in Engineering & Management Education Website: www.ijeee.in [Internet]. 2014 [cited 2024 Feb 12];1(3):2348–4748. Available from: www.ijeee.in

Orasan MS, Roman II, Coneac A, Muresan A, Orasan RI. Hair Loss And Regeneration Performed On Animal Models. Med Pharm Rep. 2016 Jul 31;89(3):327–34.

Published

2024-02-29

How to Cite

Fitriani, A. P., Wijaya, J. F., Lina, J., & Fibrini, D. (2024). Examining the Impact of Candlenut Fruit Extract Cream on Hair Growth in Male Wistar Rats (Rattus norvegicus). Poltekita : Jurnal Ilmu Kesehatan, 17(4), 1713–1721. https://doi.org/10.33860/jik.v17i4.3613

Issue

Section

Original Articles

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.