Prebiotik dan Dermatitis Atopik pada Anak
Prebiotics and Atopic Dermatitis in Children
Keywords:
Anak, Dermatitis, Atopik, PrebiotikAbstract
Dermatitis atopik adalah kondisi kulit berupa inflamasi kronis yang umum ditandai dengan gatal berulang yang parah. Gejala yang muncul termasuk kulit kering, lesi eksim, eritema (kemerahan), edema, erosi, oozing dan pengerasan kulit, yang bervariasi menurut kronisitas lesi dan usia pasien yang terkena Dermatitis atopik. Individu dengan Dermatitis atopik dalam tingkat sedang hingga berat juga dapat menunjukkan hiperpigmentasi retikulat yang didapat pada leher (juga disebut 'leher kotor') yang dihasilkan dari kombinasi hiperpigmentasi pasca inflamasi dan gesekan. Pruritus atau sensasi tidak menyenangkan pada kulit yang memicu rasa gatal sering menyebabkan trauma kulit, ketidaknyamanan, dan gangguan tidur. Memperbaiki status gizi, pencernaan nutrisi, respon imun spesifik dan non spesifik, efek menguntungkan pada saluran pencernaan dan kulit, adalah upaya untuk mendukung penggunaan pra dan probiotik pada pasien dengan Dermatitis Atopik. Namun, tidak ada cukup data dalam literatur untuk menjawab pertanyaan mengenai dosis optimal, waktu optimal untuk memulai pengobatan dan durasi yang diperlukan untuk menunjukkan efek yang menguntungkan; penggunaan probiotik yang dipersonalisasi menurut dysbiosis kolon dapat dikaitkan dengan hasil terbaik. Tinjauan pustaka ini mengkaji Prebiotik dan Dermatitis Atopik pada Anak.
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References
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24. Guarino MPL, Altomare A, Emerenziani S, Di Rosa C, Ribolsi M, Balestrieri P, et al. Mechanisms of action of prebiotics and their effects on gastro-intestinal disorders in adults. Nutrients. 2020;12(4):1037.
25. Eslami M, Bahar A, Keikha M, Karbalaei M, Kobyliak N, Yousefi B. Probiotics function and modulation of the immune system in allergic diseases. Allergol Immunopathol (Madr). 2020;
26. Yousefi B, Eslami M, Ghasemian A, Kokhaei P, Salek Farrokhi A, Darabi N. Probiotics importance and their immunomodulatory properties. J Cell Physiol. 2019;234(6):8008–18.
27. Zheng J, Feng Q, Zheng S, Xiao X. The effects of probiotics supplementation on metabolic health in pregnant women: An evidence based meta-analysis. PLoS One. 2018;13(5):e0197771.
28. Filipovic I, Lackovic M, Mihajlovic S, Filipović Đ, Bakic T, Zivkovic Z. Probiotics in Allergic Diseases. In: Atopic Dermatitis-Essential Issues. IntechOpen; 2020.
29. Myles EM, O’Leary ME, Smith R, MacPherson CW, Oprea A, Melanson EH, et al. Supplementation with Combined Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 Across Development Reveals Sex Differences in Physiological and Behavioural Effects of Western Diet in Long–Evans Rats. Microorganisms. 2020;8(10):1527.
30. Meirlaen L, Levy EI, Vandenplas Y. Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review. Nutrients. 2021;13(3):934.
31. Cione E, La Torre C, Cannataro R, Caroleo MC, Plastina P, Gallelli L. Quercetin, epigallocatechin gallate, curcumin, and resveratrol: from dietary sources to human microRNA modulation. Molecules. 2020;25(1):63.
32. Zhang J, Ma S, Wu S, Guo C, Long S, Tan H. Effects of probiotic supplement in pregnant women with gestational diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Res. 2019;2019.
33. Alizadeh-Fanalou S, Nazarizadeh A, Alian F, Faraji P, Sorori B, Khosravi M. Small dense low-density lipoprotein-lowering agents. Biol Chem. 2020;401(10):1101–21.
34. Sidbury R, Kodama S. Atopic dermatitis guidelines: Diagnosis, systemic therapy, and adjunctive care. Clin Dermatol. 2018;36(5):648–52.
35. Chernyshov P, Sampogna F, Pustišek N, Marinovic B, Manolache L, Suru A, et al. Validation of the dermatology‐specific proxy instrument the Infants and Toddlers Dermatology Quality of Life. J Eur Acad Dermatol Venereol. 2019;33(7):1405–11.
36. Bonamonte D, Filoni A, Vestita M, Romita P, Foti C, Angelini G. The role of the environmental risk factors in the pathogenesis and clinical outcome of atopic dermatitis. BioMed Res Int. 2019;2019.
37. Solomon I, Ilie MA, Draghici C, Voiculescu VM, Căruntu C, Boda D, et al. The impact of lifestyle factors on evolution of atopic dermatitis: An alternative approach. Exp Ther Med. 2019;17(2):1078–84.
38. Malmuthuge N, Griebel PJ. Fetal environment and fetal intestine are sterile during the third trimester of pregnancy. Vet Immunol Immunopathol. 2018;204:59–64.
39. Alexandre-Silva GM, Brito-Souza PA, Oliveira AC, Cerni FA, Zottich U, Pucca MB. The hygiene hypothesis at a glance: Early exposures, immune mechanism and novel therapies. Acta Trop. 2018;188:16–26.
40. Restori KH, Srinivasa BT, Ward BJ, Fixman ED. Neonatal immunity, respiratory virus infections, and the development of asthma. Front Immunol. 2018;9:1249.
41. Gholizadeh P, Mahallei M, Pormohammad A, Varshochi M, Ganbarov K, Zeinalzadeh E, et al. Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease. Microb Pathog. 2019;127:48–55.
42. Sestito S, D’Auria E, Baldassarre ME, Salvatore S, Tallarico V, Stefanelli E, et al. The role of prebiotics and probiotics in prevention of allergic diseases in infants. Front Pediatr. 2020;8.
43. Silverberg JI, Barbarot S, Gadkari A, Simpson EL, Weidinger S, Mina-Osorio P, et al. Atopic dermatitis in the pediatric population: A cross-sectional, international epidemiologic study. Ann Allergy Asthma Immunol. 2021;126(4):417–28.
44. Kim J, Kim BE, Leung DY. Pathophysiology of atopic dermatitis: clinical implications. In OceanSide Publications; 2019. p. 84.
2. Kaufman BP, Guttman‐Yassky E, Alexis AF. Atopic dermatitis in diverse racial and ethnic groups—Variations in epidemiology, genetics, clinical presentation and treatment. Exp Dermatol. 2018;27(4):340–57.
3. Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab. 2015;66(Suppl. 1):8–16.
4. Barbarot S, Auziere S, Gadkari A, Girolomoni G, Puig L, Simpson E, et al. Epidemiology of atopic dermatitis in adults: results from an international survey. Allergy. 2018;73(6):1284–93.
5. Kang S-Y, Song W-J, Cho S-H, Chang Y-S. Time trends of the prevalence of allergic diseases in Korea: a systematic literature review. Asia Pac Allergy. 2018;8(1).
6. Kakkar V, Kumar M, Saini K. An overview of atopic dermatitis with a focus on nano-interventions. Innovations. 2019;1:2019.
7. Pattipeiluhu S, Loupatty J, Pattipeilohy CE, Sambonu R. Feed efficiency in the growth of humpback grouper Cromileptes altivelis with prebiotics dietary modulation. In IOP Publishing; 2020. p. 012066.
8. Swanson KS, Gibson GR, Hutkins R, Reimer RA, Reid G, Verbeke K, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020;17(11):687–701.
9. Arshad F, Mehmood R, Hussain S, Khan MA, Khan M. Lactobacilli as probiotics and their isolation from different sources. Br J Res. 2018;5(3):43.
10. Kalil CLPV, Chaves C, De Vargas AS, Campos VB, Chagas RP, de Vento M. Use of probiotics in Dermatology-Review. Surg Cosmet Dermatol. 2020;208.
11. Kumar Verma N, Adrianus Monique van Steensel M, Prasannan P, Sheng Poh Z, Irvine AD, Oon HH. Common Skin Diseases: Chronic Inflammatory and Autoimmune Disorders. Imaging Technol Transdermal Deliv Skin Disord. 2019;35–59.
12. Smieszek SP, Przychodzen B, Welsh SE, Brzezynski JL, Kaden AR, Mohrman M, et al. Genomic and phenotypic characterization of Investigator Global Assessment (IGA) scale-based endotypes in atopic dermatitis. J Am Acad Dermatol. 2021;85(6):1638–40.
13. Tsakok T, Woolf R, Smith C, Weidinger S, Flohr C. Atopic dermatitis: the skin barrier and beyond. Br J Dermatol. 2019;180(3):464–74.
14. Quiroz FG, Fiore VF, Levorse J, Polak L, Wong E, Pasolli HA, et al. Liquid-liquid phase separation drives skin barrier formation. Science. 2020;367(6483).
15. Dorjbal B, Stinson JR, Ma CA, Weinreich MA, Miraghazadeh B, Hartberger JM, et al. Hypomorphic CARD11 mutations associated with diverse immunologic phenotypes with or without atopic disease. J Allergy Clin Immunol. 2019;143(4):1482.
16. Wollina U. Atopic dermatitis and the metabolic syndrome. Clin Dermatol. 2018;36(1):62–6.
17. Whisner CM, Castillo LF. Prebiotics, bone and mineral metabolism. Calcif Tissue Int. 2018;102(4):443–79.
18. Adler-Neal AL, Cline A, Frantz T, Strowd L, Feldman SR, Taylor S. Complementary and integrative therapies for childhood atopic dermatitis. Children. 2019;6(11):121.
19. Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, et al. Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods. 2019;8(3):92.
20. La Fata G, Weber P, Mohajeri MH. Probiotics and the gut immune system: indirect regulation. Probiotics Antimicrob Proteins. 2018;10(1):11–21.
21. Pujari R, Banerjee G. Impact of prebiotics on immune response: from the bench to the clinic. Immunol Cell Biol. 2021;99(3):255–73.
22. Martin-Gallausiaux C, Marinelli L, Blottière HM, Larraufie P, Lapaque N. SCFA: mechanisms and functional importance in the gut. Proc Nutr Soc. 2021;80(1):37–49.
23. Parada Venegas D, De la Fuente MK, Landskron G, González MJ, Quera R, Dijkstra G, et al. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol. 2019;10:277.
24. Guarino MPL, Altomare A, Emerenziani S, Di Rosa C, Ribolsi M, Balestrieri P, et al. Mechanisms of action of prebiotics and their effects on gastro-intestinal disorders in adults. Nutrients. 2020;12(4):1037.
25. Eslami M, Bahar A, Keikha M, Karbalaei M, Kobyliak N, Yousefi B. Probiotics function and modulation of the immune system in allergic diseases. Allergol Immunopathol (Madr). 2020;
26. Yousefi B, Eslami M, Ghasemian A, Kokhaei P, Salek Farrokhi A, Darabi N. Probiotics importance and their immunomodulatory properties. J Cell Physiol. 2019;234(6):8008–18.
27. Zheng J, Feng Q, Zheng S, Xiao X. The effects of probiotics supplementation on metabolic health in pregnant women: An evidence based meta-analysis. PLoS One. 2018;13(5):e0197771.
28. Filipovic I, Lackovic M, Mihajlovic S, Filipović Đ, Bakic T, Zivkovic Z. Probiotics in Allergic Diseases. In: Atopic Dermatitis-Essential Issues. IntechOpen; 2020.
29. Myles EM, O’Leary ME, Smith R, MacPherson CW, Oprea A, Melanson EH, et al. Supplementation with Combined Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 Across Development Reveals Sex Differences in Physiological and Behavioural Effects of Western Diet in Long–Evans Rats. Microorganisms. 2020;8(10):1527.
30. Meirlaen L, Levy EI, Vandenplas Y. Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review. Nutrients. 2021;13(3):934.
31. Cione E, La Torre C, Cannataro R, Caroleo MC, Plastina P, Gallelli L. Quercetin, epigallocatechin gallate, curcumin, and resveratrol: from dietary sources to human microRNA modulation. Molecules. 2020;25(1):63.
32. Zhang J, Ma S, Wu S, Guo C, Long S, Tan H. Effects of probiotic supplement in pregnant women with gestational diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Res. 2019;2019.
33. Alizadeh-Fanalou S, Nazarizadeh A, Alian F, Faraji P, Sorori B, Khosravi M. Small dense low-density lipoprotein-lowering agents. Biol Chem. 2020;401(10):1101–21.
34. Sidbury R, Kodama S. Atopic dermatitis guidelines: Diagnosis, systemic therapy, and adjunctive care. Clin Dermatol. 2018;36(5):648–52.
35. Chernyshov P, Sampogna F, Pustišek N, Marinovic B, Manolache L, Suru A, et al. Validation of the dermatology‐specific proxy instrument the Infants and Toddlers Dermatology Quality of Life. J Eur Acad Dermatol Venereol. 2019;33(7):1405–11.
36. Bonamonte D, Filoni A, Vestita M, Romita P, Foti C, Angelini G. The role of the environmental risk factors in the pathogenesis and clinical outcome of atopic dermatitis. BioMed Res Int. 2019;2019.
37. Solomon I, Ilie MA, Draghici C, Voiculescu VM, Căruntu C, Boda D, et al. The impact of lifestyle factors on evolution of atopic dermatitis: An alternative approach. Exp Ther Med. 2019;17(2):1078–84.
38. Malmuthuge N, Griebel PJ. Fetal environment and fetal intestine are sterile during the third trimester of pregnancy. Vet Immunol Immunopathol. 2018;204:59–64.
39. Alexandre-Silva GM, Brito-Souza PA, Oliveira AC, Cerni FA, Zottich U, Pucca MB. The hygiene hypothesis at a glance: Early exposures, immune mechanism and novel therapies. Acta Trop. 2018;188:16–26.
40. Restori KH, Srinivasa BT, Ward BJ, Fixman ED. Neonatal immunity, respiratory virus infections, and the development of asthma. Front Immunol. 2018;9:1249.
41. Gholizadeh P, Mahallei M, Pormohammad A, Varshochi M, Ganbarov K, Zeinalzadeh E, et al. Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease. Microb Pathog. 2019;127:48–55.
42. Sestito S, D’Auria E, Baldassarre ME, Salvatore S, Tallarico V, Stefanelli E, et al. The role of prebiotics and probiotics in prevention of allergic diseases in infants. Front Pediatr. 2020;8.
43. Silverberg JI, Barbarot S, Gadkari A, Simpson EL, Weidinger S, Mina-Osorio P, et al. Atopic dermatitis in the pediatric population: A cross-sectional, international epidemiologic study. Ann Allergy Asthma Immunol. 2021;126(4):417–28.
44. Kim J, Kim BE, Leung DY. Pathophysiology of atopic dermatitis: clinical implications. In OceanSide Publications; 2019. p. 84.
Published
2022-02-28
How to Cite
Nuur Al Azizah, F. (2022). Prebiotik dan Dermatitis Atopik pada Anak: Prebiotics and Atopic Dermatitis in Children. Svasta Harena: Jurnal Ilmiah Gizi, 2(2), 20–29. https://doi.org/10.33860/shjig.v2i2.852
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