The Effect of Moringa Leaf Extract (Moringa Oliefera) On Triglyceride Levels in Streptozotocin Induced Type 2 Diabetes White Wistar Rats

Abstract

High blood sugar levels can hasten the liver's production of triglycerides. Normally, the body uses glucose as one of its energy sources. This study aimed to determine changes in the weight of mice and decrease triglyceride levels in mice by administering Moringa leaf extract. This type of research is a pure experiment with a "pre and post-randomized controlled group" design. This was carried out using a repeated ANOVA test, a sample of 25 mice. The research used male white rats of the Wistar strain, which were induced with STZ (Streptozotocin) at a dose of 65 mg/kg BW and NA 230 mg/kg BW, where the experimental animals were divided into 5 groups, namely negative control group, positive control and 3 treatment groups given the extract. from Moringa leaves at a dose of 200, 300, 400 mg/kg BW of rats. The optimal dose of Moringa leaves for losing weight and reducing triglyceride levels in mice is a dose of 400 mg/kg of mouse body weight. Glibenclamide (0.09 mg/kg rat body weight) and Moringa leaf extract (300 mg/kg rat body weight) are each the optimal dose to reduce glucose levels in rats. With a p value for each variable of 0.001, administration of Moringa leaf extract affected body weight, glucose and triglyceride levels in white Wistar rats with type 2 diabetes induced by streptozotocin. These findings suggest that Moringa leaf extract may have potential therapeutic effects in treating diabetes-related complications.