Correlation between Oral Contraceptive Use and the Incidence of Cervical Cancer
Keywords:
Oral Contraceptive, Birth Control Pills, Cervical CancerAbstract
Cervical cancer is a malignant tumor that develops in the cervix and is the second most common type of cancer experienced by women in the world. Causes of cervical cancer include HPV infection, use of oral contraceptives, age of marriage, parity and exposure to cigarette smoke. This study aims to determine the correlation between oral contraceptive use and the incidence of cervical cancer. This literature study research involved secondary data derived from the Google Scholar, Research Gate and Science Direct databases. The keywords applied in the study were oral contraceptives, birth control pills AND cervical cancer. The journals involved were searched for similarities, dissimilarities and compared to one another. As mentioned in 11 journals, long-term use of oral contraceptives of ≥5 years could increase the risk of cervical cancer. Furthermore, three journals stated the grade of cervical precancerous lesions of CIN 2/3 as the risk factor of cervical cancer, and two journals stated the grade of cervical cancer of stage 2/2+ as the risk factor of cervical cancer. Based on the chi-square test results, 4 journals presented a significance value (p-value) of <0.05, which indicated a correlation between oral contraceptives and the incidence of cervical cancer. 9 other journals found the highest OR value = 9.11 and the lowest OR = 1.50 which meant that women who used Oral contraceptives were 9 times more at risk of developing cervical cancer. Oral contraceptive use was associated with cervical cancer based on the duration of use of more than 5 years and led to a risk of causing CIN 2/3 among women. There were other factors that could affect the incidence of cervical cancer, namely age of marriage, parity and exposure to cigarette smoke.
References
Februanti S. Asuhan Keperawatan Pada Pasien Kanker Serviks: Terintegrasi Dengan Standar Diagnosis Keperawatan Indonesia (SDKI), Standar Luaran Keperawatan Indonesia (SLKI), Dan Standar Intervensi Keperawatan Indonesia (SIKI) PPNI. Deepublish; 2019.
Kementerian Kesehatan Republik Indonesia. Profil kesehatan Indonesia Tahun 2016. Jakarta: Kementerian Kesehatan Republik Indonesia, 2016.
Raidanti D, Wahidin. Efek Kb Suntik 3 Bulan (DMPA) Terhadap Berat Badan. Literasi Nusantara; 2021.
Putra ON, Faizah AK, Sari AK. Analysis Of Factors Related To Knowledge Of Oral Contraceptives At Several Pharmacies In East Surabaya. 2021;12(1):11.
Hartanto H. Keluarga Berencana dan Kontrasepsi. In Pustaka Sinar Harapan; 2015.
Sulistiya DP, Pramono D, Nurdiati D. Faktor-faktor yang Berhubungan dengan Kejadian Kanker Serviks di Rumah Sakit Sardjito Yogyakarta. BKM. 2017;33(3):125–30.
Kusmiyati Y, Prasistyami A, Wahyuningsih HP, Widyasih H, Adnani QES. Duration of Hormonal Contraception and Risk of Cervical Cancer. Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) [Internet]. 2019 Aug 1 [cited 2022 May 19];14(1). Available from: https://www.journal.fkm.ui.ac.id/kesmas/article/view/2713
Xu H, Egger S, Velentzis LS, O’Connell DL, Banks E, Brown JD, et al. Hormonal contraceptive use and smoking as risk factors for high-grade cervical intraepithelial neoplasia in unvaccinated women aged 30–44 years: A case-control study in New South Wales, Australia - ScienceDirect [Internet]. 2018 [cited 2022 May 19]. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1877782118302339
Saleem A, Bekele A, Fitzpatrick MB, Mahmoud EA, Lin AW, Velasco HE, et al. Knowledge And Awareness Of Cervical Cancer In South Western Ethiopia Is Lacking: A Descriptive Analysis. Plos One. 2019;14(11).
Department of Cytology & Gynaecological Pathology, Postgraduate Institute of Medical Education. Guidelines for Cervical Cancer Screening Programme. Chandigarh, India; 2018.
Darusman LK, Irmanida. Domestikasi Buah Merah. PT Penerbit IPB Press; 2019. 92 p.
Iversen L, Fielding S, Lidegaard O, Hannaford PC. Contemporary Hormonal Contraception And Cervical Cancer In Women Of Reproductive Age - Iversen - 2021 - International Journal of Cancer. 2021;149(4).
Dewi IGAAN, Sawitri AAS, Mahayati NMD, Lindayani IKL. Faktor Risiko Lesi Prakanker Leher Rahim (Serviks). Penerbit Qiara Media; 2021. 63 p.
Musfirah M. Faktor Risiko Kejadian Kanker Serviks Di RSUP Dr. Wahidin Sudirohusodo Makassar. jkesmas. 2019 Jun 14;4(1):1.
Khatun SF, Khatun S, Hossain AKMF, Nahar K. Prolonged Use Of Oral Contraceptive Pill, A Co-Factor For The Development Of Cervical Cancer. Bangabandhu Sheikh Mujib Medical Univ J. 2018 Sep 1;11(3):222.
Arfailasufandi R, Mudigdo A, Faculty of Medicine, Universitas Sebelas Maret, Sudiyanto A, Faculty of Medicine, Universitas Sebelas Maret. The Effect of Obesity, Oral Contraceptive and Passive Smoking on the Risk of Cervical Cancer. J EPIDEMIOL PUBLIC HEALT. 2019;4(3):189–97.
Getinet M, Taye M, Ayinalem A, Gitie M. Precancerous Lesions of the Cervix and Associated Factors among Women of East Gojjam, Northwest Ethiopia, 2020. Cancer Manag Res. 2021 Dec 29;13:9401–10.
Santoso EB. Hubungan Usia Pertama Menikah Dengan Kejadian Kanker Serviks Di Poli Kandungan RSUD X. 2021;
Mawaddah S, Susanti ID. View of Hubungan Paritas,Usia Perkawinan Dengan Resiko Lesi Prakanker Serviks Pada Pasangan Usia Subur Di Kelurahan Petuk Bukit [Internet]. 2020 [cited 2022 Mar 7]. Available from: http://www.ejournalbidan.poltekkes-kaltim.ac.id/ojs/index.php/midwifery/article/view/136/87
Attya AM, Ali AE, AbdelSalam HS, Abdelwahab MM. Frequency of Cervical Intra-epithelial Neoplasia in Oral Contraceptive Pills Users in Zagazig University Hospitals. Zagazig University Medical Journal. 2020 Jul 1;26(4):590-7.
Utomo F, Afandi A, Rivai SB. Korelasi Durasi Penggunaan Kontrasepsi Oral Dan Stadium Kanker Serviks Di Rsud Arifin Achmad Provinsi Riau. Collaborative Medical Journal (CMJ). 2020 Jan 21;3(1):24–31.
Mustikarani IK. Hubungan Lama Penggunaan Alat Kontrasepsi Oral (Pil Kb) Dan Intrauterine Device (Iud) Terhadap Resiko Kanker Serviks Di Puskesmas Ngoresan Surakarta. Jurnal Keperawatan Malang. 2020 Dec 30;5(2):72–9.
Skorstengaard M, Lynge E, Napolitano G, Blaakær J, Bor P. Risk Of Precancerous Cervical Lesions In Women Using A Hormone-Containing Intrauterine Device And Other Contraceptives: A Register-Based Cohort Study From Denmark. Human Reproduction. 2021 Jun 18;36(7):1796–807.
Idris IM, Angka RN, Christina S, Sumbayak EM. Aktivitas Seksual Usia Dini dan Paritas Tinggi Meningkatkan Risiko Kanker Serviks. Jurnal Kedokteran Meditek. 2021 Sep 30;27(3):306–16.
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