Factors Associated with Medication Adherence Among Outpatients with Type 2 Diabetes: An Exploratory Cross-Sectional Study in Central Sulawesi, Indonesia
Abstract
Background: Medication adherence is central to type 2 diabetes management, but evidence from Central Sulawesi remains limited. Objective: To explore factors associated with medication adherence among outpatients with type 2 diabetes. Methods: This exploratory cross-sectional study used a feasibility sample of 34 patients purposively recruited at Undata General Hospital in March 2024. All 34 invited patients consented, completed the questionnaires, and were analyzed. MMAS-8 scores were classified as adherent (score 6–8) or non-adherent (score <6) for the retained binary analysis. Bivariate associations were assessed using Pearson Chi-square tests. Results: Seventeen participants (50.0%) were adherent. Spiritual well-being showed a bivariate Pearson Chi-square association (p = 0.031), whereas the other examined factors did not reach p <0.05. Conclusion: The findings identify preliminary association between spiritual well-being and medication adherence. The small purposive sample, self-reported measures, and cross-sectional design limit precision and generalizability.
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Copyright (c) 2025 Hasbunsyah Siregar, Baiq Emy Nurmalisa, Agung Prabowo
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References
Akbarpour, M. H., Khanchemehr, Y., Rafi, A., Neshati, A., Naeimi, S., & Ardali, M. N. (2025). Effect Of A Psycho-Spiritual Intervention On Medication Adherence, Self-Management, And Glycemic Control In Women With Type 2 Diabetes: A Randomized Controlled Trial. Journal Of Diabetes & Metabolic Disorders, 25(1), 4. https://doi.org/10.1007/S40200-025-01821-3
Baah-Nyarkoh, E., Alhassan, Y., Dwomoh, A. K., & Kretchy, I. A. (2023a). Medicated-Related Burden And Adherence In Patients With Co-Morbid Type 2 Diabetes Mellitus And Hypertension. Heliyon, 9(4). https://doi.org/10.1016/J.Heliyon.2023.E15448
Basu, S., Sengupta, T., & Kundu, S. (2026). Medication Adherence And Its Predictors In Patients With Type 2 Diabetes Mellitus In India: A Systematic Review And Meta-Analysis Of Current Evidence. In Health Science Reports (Vol. 9, Number 2). John Wiley And Sons Inc. https://doi.org/10.1002/Hsr2.71845
Böhm, A. K., Schneider, U., Aberle, J., & Stargardt, T. (2021). Regimen Simplification And Medication Adherence: Fixed-Dose Versus Loose-Dose Combination Therapy For Type 2 Diabetes. Plos One, 16(5 May). https://doi.org/10.1371/Journal.Pone.0250993
Cakir, L. (2025). Advances In Clinical Pharmacology And Therapeutics Polypharmacy In Type 2 Diabetes Mellitus And Related Conditions: A Double-Edged Sword: A Narrative Review. In Acpt (Vol. 2, Number 2).
Cho, N. H., Shaw, J. E., Karuranga, S., Huang, Y., Da Rocha Fernandes, J. D., Ohlrogge, A. W., & Malanda, B. (2018). Idf Diabetes Atlas: Global Estimates Of Diabetes Prevalence For 2017 And Projections For 2045. Diabetes Research And Clinical Practice, 138, 271–281. https://doi.org/10.1016/J.Diabres.2018.02.023
Horii, T., Iwasawa, M., Kabeya, Y., & Atuda, K. (2019). Polypharmacy And Oral Antidiabetic Treatment For Type 2 Diabetes Characterised By Drug Class And Patient Characteristics: A Japanese Database Analysis. Scientific Reports, 9(1). https://doi.org/10.1038/S41598-019-49424-2
Huang, J., Ding, S., Xiong, S., & Liu, Z. (2021). Medication Adherence And Associated Factors In Patients With Type 2 Diabetes: A Structural Equation Model. Frontiers In Public Health, 9. https://doi.org/10.3389/Fpubh.2021.730845
Kartini, Y., Tohri, T., & Warna, M. P. (2024). The Relationship Between Family Support And Medication Adherence In Type 2 Diabetes Patients At Cililin Hospital, Bandung, Indonesia. Health Dynamics, 1(12), 454–459. https://doi.org/10.33846/Hd11204
Kwakye, A. O., Kretchy, I. A., Peprah, P., & Mensah, K. B. (2024). Factors Influencing Medication Adherence In Co-Morbid Hypertension And Diabetes Patients: A Scoping Review. In Exploratory Research In Clinical And Social Pharmacy (Vol. 13). Elsevier Inc. https://doi.org/10.1016/J.Rcsop.2024.100426
Lestari, P., Liyanovitasari, & Prabowo, H. (2025). Medication Adherence In Patients With Diabetes Mellitus And Influencing Factors In Indonesia. Diabetes Mellitus, 28(2), 237–242. https://doi.org/10.14341/Dm13068
Lin, X., Xu, Y., Pan, X., Xu, J., Ding, Y., Sun, X., Song, X., Ren, Y., & Shan, P. F. (2020). Global, Regional, And National Burden And Trend Of Diabetes In 195 Countries And Territories: An Analysis From 1990 To 2025. Scientific Reports, 10(1). https://doi.org/10.1038/S41598-020-71908-9
Nonogaki, A., Heang, H., Yi, S., Van Pelt, M., Yamashina, H., Taniguchi, C., Nishida, T., & Sakakibara, H. (2019). Factors Associated With Medication Adherence Among People With Diabetes Mellitus In Poor Urban Areas Of Cambodia: A Cross-Sectional Study. Plos One, 14(11). https://doi.org/10.1371/Journal.Pone.0225000
Nugrahani, A. S. D., Muharram, F. R., Novida, H., Swannjo, J. B., Wibisono, S., & Wungu, C. D. K. (2025). Trends And Disability-Attributable Risk Factors Of Type 2 Diabetes Mellitus In Southeast Asia (1990–2019): An In-Depth 30-Year Analysis From The Global Burden Of Disease Study. Nutrition, Metabolism And Cardiovascular Diseases, 35(1). https://doi.org/10.1016/J.Numecd.2024.09.020
Pakaya, W., Katili, A., Basir, I. S., Studi, P., Keperawatan, I., Olahraga, F., Kesehatan, D., & Sulistiani Basir, I. (2024). The Relationship Between Family Support And Medication Adherence Among Type Ii Diabetic Patients. An Idea Health Journal, 4(2).
Piragine, E., Petri, D., Martelli, A., Calderone, V., & Lucenteforte, E. (2023). Adherence To Oral Antidiabetic Drugs In Patients With Type 2 Diabetes: Systematic Review And Meta-Analysis. In Journal Of Clinical Medicine (Vol. 12, Number 5). Multidisciplinary Digital Publishing Institute (Mdpi). https://doi.org/10.3390/Jcm12051981
Raza, M. H., Shahnaz, S., Riaz, S., Zain Ul Abideen, M., Khan Luqmani, A. I., Hayat, M. A., Murtaza, M. A., & Mansoor, S. (2026). Polypharmacy And Comorbidity Status In The Treatment Of Type 2 Diabetic Patients Attending Tertiary Care Hospitals. Indus Journal Of Bioscience Research, 4(3), 37–42. https://doi.org/10.70749/Ijbr.V4i3.2980
Shakya, P., Shrestha, A., Karmacharya, B. M., Morisky, D. E., & Kulseng, B. E. (2023). Factors Associated With Medication Adherence Among Patients With Type 2 Diabetes Mellitus: A Hospital-Based Cross-Sectional Study In Nepal. International Journal Of Environmental Research And Public Health, 20(2). https://doi.org/10.3390/Ijerph20021537
Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., Stein, C., Basit, A., Chan, J. C. N., Mbanya, J. C., Pavkov, M. E., Ramachandaran, A., Wild, S. H., James, S., Herman, W. H., Zhang, P., Bommer, C., Kuo, S., Boyko, E. J., & Magliano, D. J. (2022). Idf Diabetes Atlas: Global, Regional And Country-Level Diabetes Prevalence Estimates For 2021 And Projections For 2045. Diabetes Research And Clinical Practice, 183. https://doi.org/10.1016/J.Diabres.2021.109119
Suprapti, B., Izzah, Z., Anjani, A. G., Andarsari, M. R., Nilamsari, W. P., & Nugroho, C. W. (2023). Prevalence Of Medication Adherence And Glycemic Control Among Patients With Type 2 Diabetes And Influencing Factors: A Cross-Sectional Study. Global Epidemiology, 5. https://doi.org/10.1016/J.Gloepi.2023.100113
Tamene, F. B., Zeleke, T. K., Desalew, A. F., Tarekegn, G. Y., Sendekie, A. K., Tafere, S. M., Kiflu, M., Moges, T. A., Dagnew, F. N., & Wondm, S. A. (2025). Polypharmacy And Associated Factors Among Patients With Type Two Diabetes Mellitus With Comorbidity: A Multicenter Cross-Sectional Study In Northwest Ethiopia. Bmc Endocrine Disorders, 25(1). https://doi.org/10.1186/S12902-025-02011-1
Teng, C. L., Chan, C. W., & Wong, P. S. (2022). Medication Adherence Of Persons With Type 2 Diabetes In Malaysia: A Scoping Review And Meta-Analysis. In Journal Of The Asean Federation Of Endocrine Societies (Vol. 37, Number 1, Pp. 75–82). Asean Federation Of Endocrine Societies. https://doi.org/10.15605/Jafes.037.01.14
Wahyuni, A. S., Marwa, D., Oktasari, S. R., Yulianti, T., Nugraheni, A. Y., & Al-Samea, R. A. M. O. (2025). Determination Of Factors Affecting Medication Adherence In Type 2 Diabetes Mellitus Patients In A Tertiary Hospital: Case-Control Study. International Journal Of Applied Pharmaceutics, 17(Special Issue 2), 126–131. https://doi.org/10.22159/Ijap.2025.V17s2.20
Wibowo, M. I. N. A., Yasin, N. M., Kristina, S. A., & Prabandari, Y. S. (2022). Exploring Of Determinants Factors Of Anti-Diabetic Medication Adherence In Several Regions Of Asia – A Systematic Review. In Patient Preference And Adherence (Vol. 16, Pp. 197–215). Dove Medical Press Ltd. https://doi.org/10.2147/Ppa.S34707
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